Bornavirus

The virus of Borna disease (BDV) is the only representative of the family in the order Mononegavirales Borna disease. It is a neurotropic virus that presents a noncytolytic strategy for replication in cells. Epidemiological studies have shown that natural infection with BDV occurs in a wide variety of guests. Natural infections have been reported symptomatic with BDV in cats, dogs and rabbits, resulting in the death of the animal. It is also possible asymptomatic infection, as some studies suggest that the host range for BDV includes all warm-blooded animals. (4, 5)
Early studies of bornavirus in birds occurred in Psittaciformes suffering from proventricular dilatation syndrome. In this condition the birds are unable to properly digest food. Even in some animals can break the wall of the proventriculus, resulting in the discharge of undigested food in the abdominal cavity, causing severe infections that end in death. (4, 5) In 2008 it was found that this disease was caused by BDV. (1)
Bioingentech can detect Bornavirus using the following techniques, supported by the World Organisation for Animal Health (OIE) (2, 3):

Bibliography

• Kistler AL, Gancz A, Clubb S, Skewes-Cox P, Fischer K, Sorber K, et al. Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent. Virol J. 2008;5:88
• OIE, Código Sanitario para los Animales Terrestres 2010, vols. I & II, 19a ed., 2010.
• Sambrook J, Frisch EF, Maniatis T. Molecular Cloning, A laboratory manual, 2a ed. 1990.
• Tomonaga K, Kobayashi T, Ikuta K. Molecular and cellular biology of Borna disease virus infection. Microbes Infect. 2002 Apr;4(4):491-500.
• Weissenböck H, Bakonyi T, Sekulin K, Ehrensperger F, Doneley RJ, Dürrwald R, Hoop R, Erdélyi K, Gál J, Kolodziejek J, Nowotny N. Avian bornaviruses in psittacine birds from Europe and Australia with proventricular dilatation disease. Emerg Infect Dis. 2009 Sep;15(9):1453-9.